en فیزیولوژی ورزشی Sport Physiology Research Article Research Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><b>Background:</b> This study investigated the impact of a 3-week detraining period, followed by 10 weeks of aerobic training, on the serum levels of osteocalcin and alkaline phosphatase (ALP) in asthmatic males.<br> <b>Methods:</b> Thirty adult males with asthma were randomly divided into experimental and control groups. The experimental group engaged in a 10-week aerobic training program, which included running sessions 3 times per week for 30-60 minutes each, maintaining a target heart rate range of 55%-75% of their maximum heart rate (HRmax). In contrast, the control subjects did not participate in any exercise activities during the study period. Fasting blood samples were obtained at baseline, after aerobic training, and after detraining to measure the levels of osteocalcin and ALP in both groups.<br> <b>Results:</b> The 10-week aerobic training program led to a significant increase in levels of osteocalcin and ALP in the experimental group, but following the detraining period, these variables returned to their pre-training levels.<br> <b>Conclusion: </b>The effectiveness of continuous aerobic training on bone formation markers in asthmatic patients will disappear after a relatively short period of detraining. This evidence emphasizes the lack of stopping aerobic exercise in the presence of inhaled corticosteroids with the aim of improving bone metabolism in asthmatic patients.</span></span> Aerobic exercise, Detraining, Asthma, Osteoporosis. 13 16 http://mlj.goums.ac.ir/browse.php?a_code=A-10-756-1&slc_lang=en&sid=1 Mazaher Habibnezhad habibnemazaher@gmail.com 100319475328460031908 100319475328460031908 No Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran Babisan Askari babisan.askari@gmail.com 100319475328460031909 100319475328460031909 Yes Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran Saqqa Farajtabar Behrestaq farajtabarp@yahoo.com 100319475328460031910 100319475328460031910 No Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran Asra Askari askari.asra@gmail.com 100319475328460031911 100319475328460031911 No Department of Physical Education and Sport Sciences, Gorgan Branch, Islamic Azad University, Gorgan, Iran